The Antioxidative and Antimicrobial Activity of 2-Amino Substituted Halochalcone N-Glycoside Derivative Compounds


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DOI:

https://doi.org/10.62482/pmj.13

Keywords:

Antimicrobial activity, antioxidant activity, halochalcone, N- glycoside

Abstract

Introduction: The aim of this study was to specify the antioxidant and antimicrobial activity synthesized 2-amino substituted halochalcone N-glycoside derivative compounds. Methods: The antioxidant capacity of synthesized compounds (1-4) was determined by cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP). Antimicrobial activity was determined on 9 microorganism by agar well diffusion method.
Results: According to the study results, compound 3 showed the highest antioxidant activity. The compound 3 showed antimicrobial activity against Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Candida albicans while compound 4 showed antimicrobial activity against Escherichia coli, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, Staphylococcus aureus.
Conclusion: 2-amino substituted halochalcone N-glycoside derivative compounds could be evaluated in the pharmaceutical and cosmetic fields due to their antioxidant and antimicrobial potential.

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Published

2024-10-31

How to Cite

Aliyazicioglu, R., Yikilmaz, M., Kanbolat, S., Badem, M., Fandakli, S., & Alpay Karaoglu, S. (2024). The Antioxidative and Antimicrobial Activity of 2-Amino Substituted Halochalcone N-Glycoside Derivative Compounds. Pharmedicine Journal, 1(3), 121–127. https://doi.org/10.62482/pmj.13

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